IFNW1 Protein (His Tag)

Sino Biological Inc. liefert IFNW1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von IFNW1 Protein

QC Testing von IFNW1 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: IFNW1 protein
Bio-activity	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The ED50 for this effect is typically 2-8 pg/mL.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 22
Molecular Mass	The recombinant human IFNW1 consists of  185 amino acids and predicts a molecular mass of 21.6 KDa. It migrates as an approximately 22 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IFNW1 Protein

Verwandte Produkte & Themen von IFNW1 Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-10/Interferon Family>>IFN omega/IFNW

Beschreibung von IFNW1 Protein

IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I  and type I I, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN α, β, τ, and ω and bind to the type I  IFN receptor, whereas IFN-γ is the only type I I IFN and is specific for the type I I IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 10%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.

References

1. Holly M Horton. et al., 1999, Cancer Research. 59: 4064-8.
2. Rudolf Hauptmann Peter Swetly. 1985, Nucleic Acids Research. 13 (13): 4739-49.
3. Günther R Adolf. et al., 1990, The Journal of Biological Chemistry. 265 (16): 9290-5.