EPHB3 / HEK2 (aa 585-998) Protein (GST Tag)

Sino Biological Inc. liefert EPHB3 / HEK2 (aa 585-998) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über EPHB3 / HEK2 (aa 585-998) Protein (GST Tag) lesen Sie bitte: http://www.sinobiological.com/EPHB3-HEK2-Protein-g-9937.html

Produkt-Information von EPHB3 / HEK2 Protein

QC Testing von EPHB3 / HEK2 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: EPHB3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human EPHB3 /GST chimera consists of  651 amino acids and has a calculated molecular mass of 74.7 kDa. The recombinant protein migrates as an approximately 64 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH7.4, 10%gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EPHB3 / HEK2 Protein

Verwandte Produkte & Themen von EPHB3 / HEK2 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB3/HEK2

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>EphB3/HEK2

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>EphB3/HEK2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EphB3/HEK2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>EphB3/HEK2

Beschreibung von EPHB3 / HEK2 Protein

Ephrin type-B receptor 3, EPH-like kinase 2, Tyrosine-protein kinase TYRO6, EPHB3, ETK2, HEK2 and TYRO6, is a single-pass type I  membrane protein which belongs to the protein kinase superfamily, tyr protein kinase family, ephrin receptor subfamily. EPHB3 contains two fibronectin type-III domains, one protein kinase domain and one SAM (sterile alpha motif) domain. EphB3 is initially expressed in the sclerotome, but later is expressed predominantly in the dermatome. It is prominent expression is also detected in the developing heart, liver, posterior ventral limb bud mesenchyme, pharyngeal arches, and head mesenchyme. The EphB3 receptors are expressed during embryonic development in multiple regions of the central nervous system. The spatial profile of EphB3 receptors is co-localized to regions of the brain that had a high level of EphB3 receptor binding ligands. Its expression pattern suggests that EphB3 may play a role in the maintenance of mature neuronal connections or re-arrangement of synaptic connections during late stages of development. EphB3-ephrin-B interaction promotes MET by re-establishing epithelial cell-cell junctions and such an MET-promoting effect contributes to EphB3-mediated tumor suppression.

References

1. Baker RK. et al., 2001, Mech Dev. 104 (1-2): 129-32.
2. Willson CA. et al., 2003, Cell Transplant. 12 (3): 279-90.
3. Willson CA. et al., 2006, J Mol Histol. 37 (8-9): 369-80.
4. Risley M. et al., 2009, Mech Dev. 126 (3-4): 230-9.
5. Chiu ST. et al., 2009, Carcinogenesis. 30 (9): 1475-86.