Epcr / PROCR Protein (His Tag)

28.03.2012

Produkt-Information von Epcr / PROCR Protein

Synonym	CCCA, CCD41, CD201, EPCR, bA42O4.2
Protein Construction	A DNA sequence encoding the extracellular domain of human PROCR (Q9UNN8) (Met 1- Thr 209), was fused with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

Epcr / PROCR Protein QC Testing

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE Epcr / PROCR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 18
Molecular Mass	The secreted recombinant human PROCR consists of 203 amino acids and has a predicted molecular mass of 23.4 kDa. The apparent molecular mass of rhPROCR is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Epcr / PROCR Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Epcr / PROCR Protein

Endothelial protein C receptor (EPCR), also known as activated protein C receptor (APC receptor) or PROCR, is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells(cells on the inside of blood vessels), activated protein C is found maily near endothelial cells. Protein C is pleiotropic, with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occur when it does not. When still bound to EPCR, activated protein C performs its cytoprotective effects.

References

Nicolaes GA. et al., 2003, Semin Vasc Med. 3 (1): 33-46.
Esmon CT. 2003, Chest. 124 (3): 26-32.
Mosnier LO. et al., 2007, Blood. 109: 3161-3172.

Sino Biological Inc. liefert Epcr / PROCR Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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