Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native)

08.03.2013

Sino Biological Inc. liefert Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Danio rerio (zebrafish) BMP-2 / BMP2A Protein (Native) lesen Sie bitte:http://www.sinobiological.com/BMP-2-BMP2A-Protein-g-10558.html

Produkt-Information von BMP-2 / BMP2A Protein

Synonym	BMP2A
Protein Construction	A DNA sequence encoding the zebrafish BMP2A (B3DI86) (Gln272-Arg386) was expressed and purified with an initial Met.
Source	Danio rerio (zebrafish)
Expression Host	E.coli

QC Testing von BMP-2 / BMP2A Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: BMP-2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant zebrafish BMP2A consists of 116 amino acids and has a calculated molecular mass of 13.2 kDa. It migrates as an 13 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 30mM HAC, pH 3.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von BMP-2 / BMP2A Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von BMP-2 / BMP2A Protein

Bone morphogenetic protein 2 (BMP2) is a member of the BMP subgroup belonging to the transforming growth factor (TGF)-beta superfamily. The mature BMP2 acts as disulfide-linked homodimers and heterodimers with BMP-7 after proteolytic removal of propeptide. BMP2 is capable of inducing the formation of cartilage and bone but are now regarded as multifunctional cytokines. It binds heterodimeric receptor complexes composed of a type I receptor and a type I I receptor, and transduces the related signals via the down-stream molecules, such as the PI3 kinase, Smads, STATs, etc. BMP2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types, and induce apoptosis in human myeloma cell lines as a novel function. In addition, recent studies have revealed that osteoblast-derived BMP2 enhances the migration of prostate cancer cells. rhBMP2 can be utilized in various therapeutic interventions such as bony defects, delayed union, non-union fractures and osteoporosis.

References

Wozney JM. et al., 1988, Science. 242: 1528-34.
Chen D. et al., 2004, Growth Factors. 22: 233-41.
Kawamura C. et al., 2000, Blood. 96: 2005-11.
Lai TH. et al., 2008, Prostate. 68: 1341-53.
Ghosh-Choudhury N. et al., 2002, J Biol Chem. 277: 33361-8.
Hallahan AR. et al., 2003, Nat Med. 9: 1033-8.

Cytokine

TGF-beta