Cynomolgus Interferon alpha-B / IFNA8 Protein

08.06.2013

Sino Biological Inc. liefert Cynomolgus Interferon alpha-B / IFNA8 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus Interferon alpha-B / IFNA8 Protein lesen Sie bitte:http://www.sinobiological.com/Interferon-alpha-B-IFNA8-Protein-Antibody-a-6207.html

Produkt-Information von Interferon alpha-B / IFNA8 Protein

Synonym	IFNA8
Protein Construction	A DNA sequence encoding the cynomolgus IFNA8(G7PS89) (Met1-Glu189) was expressed with Fc region of mouse IgG at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von Interferon alpha-B / IFNA8 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IFNA8 protein
Bio-activity	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitisvirus (VSV). The ED50 for this effect is typically 0.1-0.6 ng/mL.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 24
Molecular Mass	The recombinant cynomolgus IFNA8 is a disulfide-linked homodimer. The reduced monomer comprises 400 amino acids and has a calculated molecular mass of 46 KDa.The apparent molecular mass of the protein is approximately 48 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, PH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von Interferon alpha-B / IFNA8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von Interferon alpha-B / IFNA8 Protein

Interferon alpha-B, also known as IFNA8, belongs to the alpha/beta interferon family. Interferons are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, parasites or tumorcells. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They also allow for communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. Interferons also activate immune cells, such as natural killer cells and macrophages. They increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes. They also increase the ability of uninfected host cells to resist new infection by virus. Certain symptoms, such as aching muscles and fever, are related to the production of IFNs during infection. Produced by macrophages, IFN-alpha have antiviral activities.

References

Henco K. et al., 1985, J Mol Biol. 185 (2): 227-60.
Goeddel DV. et al., 1981, Nature. 290 (5801): 20-6.
Yelverton E. et al., 1981, Nucleic Acids Res. 9 (3): 731-41.
Kempaiah P. et al., 2012, Hum Genet. 131 (8): 1375-91.