Cynomolgus IFNAR1 / IFNAR Protein (His Tag) (Cytokine)

Sino Biological Inc. liefert Cynomolgus IFNAR1 / IFNAR Protein (His Tag) (Cytokine) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IFNAR1 / IFNAR Protein (His Tag) (Cytokine) lesen Sie bitte: http://www.sinobiological.com/IFNAR1-Protein-Antibody-a-1175.html

Produkt-Information von IFNAR1 / IFNAR Protein

QC Testing von IFNAR1 / IFNAR Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IFNAR1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Lys 28
Molecular Mass	The recombinant cynomolgus IFNAR1 comprises 421 amino acids and has a calculated molecular mass of 48.7 KDa. The apparent molecular mass of the protein is approximately 69-79 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile AAAAAAAA Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IFNAR1 / IFNAR Protein

Verwandte Produkte & Themen von IFNAR1 / IFNAR Protein

Beschreibung von IFNAR1 / IFNAR Protein

Interferon alpha/beta receptor 1, also known as IFN-alpha/beta receptor 1, Type I interferon receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFNAR1 and IFNAR, is a single-pass type I membrane protein which belongs to the type I I cytokine receptor family. IFNAR1 is a receptor for interferons alpha and beta which contains three fibronectin type-III domains. The binding of IFNAR1 to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Ubiquitination, endocytosis, and lysosomal degradation of the IFNAR1 subunit of the type I interferon (IFN) receptor is mediated by the SCFbeta-Trcp (Skp1-Cullin1-F-box protein beta transducin repeat-containing protein) E3 ubiquitin ligase in a phosphorylation-dependent manner. Stability of IFNAR1 is regulated by its binding to Tyk2 kinase. Expression of Tyk2 stabilized IFNAR1 in a manner that was dependent neither on its binding to beta-Trcp nor IFNAR1 ubiquitination.

References

1. Abramovich C. et al., 1994, FEBS Lett. 338: 295-300.
2. Colamonici O. et al., 1994, Mol Cell Biol. 14: 8133-42.
3. Kumar KG. et al., 2004, J Biol Chem. 279 (45): 46614-20.
4. Gauci S. et al., 2009, Anal Chem. 81: 4493-501.
5. Wollscheid B., et al., 2009, Nat Biotechnol. 27: 378-86.
6. Mayya V. et al., 2009, Sci Signal. 2: RA46-RA46.

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