Cynomolgus CXCL9 / C-X-C motif chemokine 9 Protein (Native) (Cytokine)

03.04.2013

Sino Biological Inc. liefert Cynomolgus CXCL9 / C-X-C motif chemokine 9 Protein (Native) (Cytokine) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus CXCL9 / C-X-C motif chemokine 9 Protein (Native) (Cytokine) lesen Sie bitte: http://www.sinobiological.com/CXCL9-MIG-Protein-a-2423.html

Produkt-Information von CXCL9 / C-X-C motif chemokine 9 Protein

Synonym	CXCL9
Protein Construction	A DNA sequence encoding the cyno CXCL9 (Thr23-Thr125) was expressed and purified with an initial Met.
Source	Cynomolgus
Expression Host	E.coli

QC Testing von CXCL9 / C-X-C motif chemokine 9 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CXCL9 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant cyno CXCL9 consists of 104 amino acids and has a calculated molecular mass of 11.9 kDa. It migrates as an 15 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CXCL9 / C-X-C motif chemokine 9 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CXCL9 / C-X-C motif chemokine 9 Protein

C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, Small-inducible cytokine B9 and CXCL9, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL9 is a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. CXCL9 binds to CXCR3. CXCR3 ligand CXCL9 is involved in regulation of the allergic response in the lung by regulation of lymphocyte activation and eosinophil recruitment. CXCL9 has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection. Measurement of pretransplant serum CXCL9 levels might represent the tracking of a clinically useful parameter to identify subjects at high risk of acute rejection (AR) and graft failure. CXCL9 might be used for the individualization of immunosuppressive therapies.

References

Thomas MS. et al., 2004, J Immunol. 173 (1): 615-23.
Hasan Z. et al., 2009, PLoS One. 4 (4): e5158.
Menke J. et al., 2008, J Am Soc Nephrol. 19 (6): 1177-89.
Rotondi M. et al., 2010,Transpl Int. 23 (5): 465-75.
Higurashi M. et al., 2009, J Diabetes Complications. 23 (3): 178-84.

Cytokine

Chemokine