Cynomolgus IFNA13 / Interferon alpha-13 Protein

12.03.2013

Sino Biological Inc. liefert Cynomolgus IFNA13 / Interferon alpha-13 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IFNA13 / Interferon alpha-13 Protein lesen Sie bitte: http://www.sinobiological.com/IFNA13-Interferon-alpha-13-Protein-g-10581.html

Produkt-Information von IFNA13 / Interferon alpha-13 Protein

Synonym	IFNA13
Protein Construction	A DNA sequence encoding the cynomolgus IFNA13(G7NFW4) (Met1-Glu190) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IFNA13 / Interferon alpha-13 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: IFNA13 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 25
Molecular Mass	The recombinant cynomolgus IFNA13 is a disulfide-linked homodimer. The reduced monomer comprises 407 amino acids and has a calculated molecular mass of 46.4 KDa.The apparent molecular mass of the protein is approximately 47 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IFNA13 / Interferon alpha-13 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IFNA13 / Interferon alpha-13 Protein

Interferon alpha-13, also known as IFN-alpha-13, Interferon alpha-D, and IFNA13, is a secreted protein which belongs to the alpha / beta interferon family. Interferon alpha-13 / IFNA13 is produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferons (IFNs) are proteins made and released by host cells in response to the presence of pathogens such as viruses, bacteria, or parasites or tumor cells. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogens or tumors. IFNs belong to the large class of glycoproteins known as cytokines. IFNs have other functions: they activate immune cells, such as natural killer cells and macrophages; they increase recognition of infection or tumor cells by up-regulating antigen presentation to T lymphocytes; and they increase the ability of uninfected host cells to resist new infection by virus. Certain host symptoms, such as aching muscles and fever, are related to the production of IFNs during infection.

References

Humphray SJ. et al., 2004, Nature. 429: 369-74.
Liu YJ. et al., 2005, Annu Rev Immunol. 23: 275-306.
Fensterl V. et al., 2009, Biofactors. 35 (1): 14-20.

Cytokine