Cynomolgus IL10RA Protein

13.03.2013

Sino Biological Inc. liefert Cynomolgus IL10RA Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IL10RA Protein lesen Sie bitte: http://www.sinobiological.com/IL10RA-Protein-g-10582.html

Produkt-Information von IL10RA Protein

Synonym	IL10RA
Protein Construction	A DNA sequence encoding the cynomolgus IL10RA(Thr9-Asn245) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IL10RA Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL10RA protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 29
Molecular Mass	The recombinant cynomolgus IL10RA is a disulfide-linked homodimer. The reduced monomer comprises 458 amino acids and has a calculated molecular mass of 51.8 KDa.The apparent molecular mass of the protein is approximately 62-66 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IL10RA Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IL10RA Protein

CD219, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also recently been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD219 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD219 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD219 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

References

Josephson K. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57 (12): 1908-11.
Tan J C. et al., 1995, J Biol Chem. 270 (21): 12906-11.
Josephson K. et al., 2001, Immunity. 15 (1): 35-46.

Cytokine