Cynomolgus IFNA2 / Interferon alpha 2 Protein

12.03.2013

Sino Biological Inc. liefert Cynomolgus IFNA2 / Interferon alpha 2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus IFNA2 / Interferon alpha 2 Protein lesen Sie bitte: http://www.sinobiological.com/IFNA2-Interferon-alpha-2-Protein-g-10580.html

Produkt-Information von IFNA2 / Interferon alpha 2 Protein

Synonym	IFNA2
Protein Construction	A DNA sequence encoding the cynomolgus IFNA2 (Met1-Glu188) was expressed with Fc region of mouse IgG at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von IFNA2 / Interferon alpha 2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IFNA2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 24
Molecular Mass	The recombinant cynomolgus IFNA2 is a disulfide-linked homodimer. The reduced monomer comprises 399 amino acids and has a calculated molecular mass of 45.9 KDa.The apparent molecular mass of the protein is approximately 47 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, PH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von IFNA2 / Interferon alpha 2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von IFNA2 / Interferon alpha 2 Protein

Interferon alpha 2 (IFN-alpha 2) is a member of the IFN alpha protein family. The IFN alpha proteins are produced by leukocytes. They are mainly involved in innate immune response against viral infection. IFN alpha acts as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus thus causing fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2 (PGE2). A similar mechanism is used by IFN alpha to reduce pain; IFN alpha interacts with the μ-opioid receptor to act as an analgesic. Interferon alpha 2 (IFN-alpha 2) was isolated from a preparation of partially purified human leucocyte IFN by monoclonal-antibody immunoaffinity chromatography. Interferon alpha-2 (IFN alpha 2) is a leukocyte product with several biological properties including antiviral activity, pyrogenicity and enhancement of immune functions. It has been reported that an additional facet of Interferon alpha-2 activity is its ability to enhance slow-wave sleep (SWS) without greatly altering other aspects of sleep. The sleep-promoting activity of Interferon alpha-2 may be related to feelings of lassitude and sleepiness that often accompany viral disease and interferon therapy. Recombinant alpha-2 interferon has been used in the treatment of Kaposi's sarcoma, and its toxicity and efficacy is associated with the acquired immunodeficiency syndrome.

References

Wang. et al., 2004, J Neuroimmunol. 156 (1-2): 107-12.
Groopman JE. et al., 1984, Ann Intern Med. 100 (5): 671-6.
Krueger JM. et al., 1987, Int J Immunopharmacol. 9 (1): 23-30.

Cytokine