Cynomolgus CD53 (aa 107-181) Protein (His Tag)

16.04.2013

Sino Biological Inc. liefert Cynomolgus CD53 (aa 107-181) Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus CD53 (aa 107-181) Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CD53-Protein-a-5764.html

Produkt-Information von CD53 Protein

Synonym	CD53
Protein Construction	A DNA sequence encoding the cynomolgus CD53 (G7NW46) (Glu107-Asn181) was expressed with a polyhistide tag at the N-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von CD53 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CD53 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant heterodimer of cynomolgus CD53 comprises 95 amino acids and has a calculated molecular mass of 10.7 KDa. The apparent molecular mass of the protein is approximately 19-22 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CD53 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CD53 Protein

CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

References

Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.

CD53 related areas, pathways, and other information