Cynomolgus ACVR1B / ALK-4 Protein

06.12.2012

Sino Biological Inc. liefert Cynomolgus ACVR1B / ALK-4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cynomolgus ACVR1B / ALK-4 Protein lesen Sie bitte: http://www.sinobiological.com/ACVR1B-ALK-4-Protein-g-9965.html

Produkt-Information von ACVR1B / ALK-4 Protein

Synonym	ACVR1B
Protein Construction	A DNA sequence encoding the cynomolgus ACVR1B(F7HNS7) (Met1-Glu126) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Cynomolgus
Expression Host	Human Cells

QC Testing von ACVR1B / ALK-4 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: ACVR1B protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Arg 27
Molecular Mass	The recombinant cynomolgus ACVR1B is a disulfide-linked homodimer. The reduced monomer comprises 341 amino acids and has a calculated molecular mass of 38.2 KDa.The apparent molecular mass of it is approximately 44 KDa respectively in SDS-PAGE.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ACVR1B / ALK-4 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ACVR1B / ALK-4 Protein

Activin receptor type-IB, also known as Serine/threonine-protein kinase receptor R2, Activin receptor-like kinase 4, ALK-4, and ACVRIB, is a single-pass type I membrane protein which belongs to the protein kinase superfamily and TGFB receptor subfamily. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type I I (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. ALK-4 is expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver. ALK4 and ALK7 can mediate signal transduction by Nodal proteins, although ALK7 appears to be a receptor more specifically dedicated to Nodal signaling.

References

Reissmann E. et al., 2001, Genes Dev. 15 (15): 2010-22.
Su GH. et al., 2001, Proc Natl Acad Sci . 98 (6): 3254-7.
Inman GJ. et al., 2002, Mol. Pharmacol. 62 (1): 65-74.
Harrison CA. et al., 2003, J. Biol. Chem. 278 (23): 21129-35.

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
ALK-4/ACVR1B	Human	ALK-4/ACVR1B/Fc Protein, Recombinant	10583-H03H
ALK-4/ACVR1B	Human	ALK-4/ACVR1B Protein, Recombinant	10583-H08H
ALK-4/ACVR1B	Cynomolgus	ACVR1B / ALK-4 Protein, Recombinant	90066-C02H

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human ALK-4/ACVR1B	WB, ELISA	ALK-4/ACVR1B Antibody, Mouse MAb	10583-MM01