Rat CD5 Protein

Sino Biological Inc. liefert Rat CD5 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD5 Protein lesen Sie bitte: http://www.sinobiological.com/CD5-Protein-g-9964.html

Produkt-Information von CD5 Protein

QC Testing von CD5 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: CD5 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 24
Molecular Mass	The recombinant rat CD5/Fc is a disulfide-linked homodimer. The reduced monomer comprises 586 amino acids and has a predicted molecular mass of 64.5 kDa. The apparent molecular mass of the protein is approximately 85 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD5 Protein

Verwandte Produkte & Themen von CD5 Protein

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD5

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>CD5

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD5

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD5

Cardiovascular>>Lipid Metabolism>>Scavenger Receptor>>CD5

Beschreibung von CD5 Protein

T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I  membrane protein. CD5 contains 3 SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

References

1. Heuring AH. et al., 2001, The British journal of ophthalmology. 85 (4): 498-9.
2. Dalloul A. 2009, Autoimmun Rev. 8 (4): 349-53.
3. Pospisil R. et al., 2009, Mol Immunol. 46 (13): 2456-64.