Cyclophilin A / PPIA Antikörper (Antigen Affinität reinigt)

06.03.2012

Produkt-Information von Cyclophilin A / PPIA Antikörper

Immunogen	Recombinant Mouse Cyclophilin A / PPIA protein (Catalog#50296-M08E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse Cyclophilin A / PPIA (rM Cyclophilin A / PPIA; Catalog#50296-M08E; NP_032933.1; Met 1-Leu 164). Cyclophilin A / PPIA specific IgG was purified by Mouse Cyclophilin A / PPIA affinity chromatography.

Cyclophilin A / PPIA Antikörper Usage Guide

Specificity	Mouse Cyclophilin A / PPIA
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PPIA in WB. Using a DAB detection system, the detection limit for Mouse PPIA is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse PPIA. The detection limit for Mouse PPIA is approximately 0.039 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Cyclophilin A / PPIA Antikörper

Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to thecyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.

References

Braaten,D. et al., 1996,Cytogenet Cell Genet74 (4):262.
Colgan, J. et al., 2000,Genomics68 (2):167-78.
An, P.et al., 2007, PLoS Pathog. 3 (6):e88.
Palacin, M. et al.,2008, Int J Immunogenet35 (2):159-64.

Sino Biological Inc. liefert Cyclophilin A / PPIA Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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