CD200RLa / CD200R1L Antikörper (Antigen Affinität reinigt)

06.03.2012

Produkt-Information von CD200RLa / CD200R1L Antikörper

Immunogen	Recombinant Human CD200RLa / CD200R1L protein (Catalog#11620-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human CD200RLa / CD200R1L (rh CD200RLa / CD200R1L; Catalog#11620-H08H; NP_001008784.2; Met 1-Leu 239, one aa mutation 113Arg /Leu ). CD200RLa / CD200R1L specific IgG was purified by Human CD200RLa / CD200R1L affinity chromatography.

CD200RLa / CD200R1L Antikörper Usage Guide

Specificity	Human CD200RLa / CD200R1L
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CD200R1L in WB. Using a DAB detection system, the detection limit for Human CD200R1L is approximately 0.5 ng/lane under non-reducing conditions reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CD200R1L. The detection limit for Human CD200R1L is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von CD200RLa / CD200R1L Antikörper

Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I membrane protein which belongs to theCD200R family. CD200R1L / CD200R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD200 is a transmembrane protein delivering immunoregulatory signals after engagement of CD200R. A family of CD200Rs exist (CD200R1, CD200R2, CD200R3, CD200R4) with different tissue expression and functional activity. In the presence of anti-CD200R2 / CD200R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD200 and one of its receptors, CD200R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3 (+) regulatory T cells. Unlike anti-CD200R1, anti-CD200R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.

References

Wright G.J.et al., 2003, J. Immunol. 171: 3034-46.
Gorczynski R.M.et al. 2004, Am. J. Reprod. Immunol. 52: 147-63.
Muzny D.M. et al., 2006, Nature 440: 1194-8.

Sino Biological Inc. liefert CD200RLa / CD200R1L Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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