CXCL5 Protein (Native)

23.11.2012

Sino Biological Inc. liefert CXCL5 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CXCL5 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/CXCL5-Protein-g-9906.html

Produkt-Information von CXCL5 Protein

Synonym	CXCL5, ENA78, SCYB5
Protein Construction	A DNA sequence encoding the human CXCL5 (P42830) (Arg45-Asn114) was expressed, with a N-terminal Met.
Source	Human
Expression Host	E.coli

QC Testing von CXCL5 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CXCL5 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human CXCL5 consists of 71 amino acids and predicts a molecular mass of 7.8 KDa. It migrates as an approximately 8 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 80% acetonitrile 0.1%TFA 20%H2O. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CXCL5 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CXCL5 Protein

CXCL5 is a small cytokine which belongs to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. It is expressed in eosinophils, and can be inhibited with the type II interferon. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It also stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2. CXCL5 has been implicated in connective tissue remodelling.

References

Dawes JM. et al., 2011, Sci Transl Med. 3 (90): 90ra60.
O'Donovan N. et al., 1999, Cell Genet. 84 (1-2): 39-42.
Persson T. et al., 2003, Clin Exp Allergy. 33 (4): 531-7.