CSF1R / M-CSFR / CD115 (aa 543-922) Protein (GST Tag)

Produkt-Information von CSF1R / M-CSFR / CD115 Protein

QC Testing von CSF1R / M-CSFR / CD115 Protein

Purity	> 82 % as determined by SDS-PAGE	SDS-PAGE: CSF1R / M-CSFR / CD115 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human CSF1R (aa 543-922) /GST chimera consists of 617 amino acids and has a calculated molecular mass of 71 KDa. It migrates as an approximately 60 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 50mM Tris,100mM NaCl, 20% gly，0.3mM DTT,pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CSF1R / M-CSFR / CD115 Protein

Verwandte Produkte & Themen von CSF1R / M-CSFR / CD115 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Immunology>>Cytokine & Receptor>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CSF1R/MCSF Receptor/CD115

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CSF1R/MCSF Receptor/CD115

Beschreibung von CSF1R / M-CSFR / CD115 Protein

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1, a cytokine involved in the proliferation, differentiation, and activation of macrophages. As a member of the typeIII subfamily of receptor tyrosine kinases (RTKs), M-CSF receptor is expressed mainly on cells of monocyte/macrophage lineage, and consists of an extracellular ligand-binding domain and a cytoplasmic protein tyrosine kinase (PTK) domain joined through a single transmembrane helix. Ligand binding induces the M-CSF receptor homodimerization, and leads to transphosphorylation of specific tyrosine and the subsequent signal transduction. This activated receptor exerts actions on multiple intracellular effectors which determine the magnitude and specificity of the biological responses, and thus mediates most if not all of the biological effects of the CSF1 cytokine, including cell growth, survival, differentiation and chemotaxis. Mutations of this gene have been associated with a predisposition to myeloid malignancy.

References

1. Sherr CJ. 1988, Biochim Biophys Acta. 948: 225-43.
2. Rohrschneider LR. et al., 1997, Mol Reprod Dev. 46: 96-103.
3. Hamilton JA. et al., 1997, J Luekoc Biol. 62: 145-55.
4. Roussel MF. et al., 1991, Nature. 353: 361-3.
5. Yeung Y. et al., 1998, J Biol Chem. 273.
6. Pixley FJ. et al., 2004, Trends Cell Biol. 14: 628-38.
7. Rovida E. et al., 2001, J Immunol. 166: 1583-9.

Sino Biological Inc. liefert CSF1R / M-CSFR / CD115 (aa 543-922) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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