BAFF / TNFSF13B Protein (Native)

23.04.2012

Produkt-Information von BAFF / TNFSF13B Protein

Synonym	TNFSF13B ,BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK,TNFSF20, ZTNF4
Protein Construction	A DNA sequence encoding the soluble form of human BAFF (Q9Y275-1) (Ala 134-Leu 285) was expressed and purified.
Source	Human
Expression Host	E.coli

QC Testing von BAFF / TNFSF13B Protein

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: BAFF / TNFSF13B protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 1
Molecular Mass	The recombinant human BAFF consisting of 153 amino acids and has a calculated molecular mass of 17.2 KDa. It migrates as an approximately 14KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von BAFF / TNFSF13B Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von BAFF / TNFSF13B Protein

Related Areas:

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>BLyS/TNFSF13B/CD257

Immunology>>Cytokine & Receptor>>TNF Superfamily>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Co-stimulatory Molecules>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>BLyS/TNFSF13B/CD257

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>BLyS/TNFSF13B/CD257

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
BLyS/TNFSF13B	Human	BLyS/TNFSF13B Protein, Recombinant	10056-H01H
BLyS/TNFSF13B	Human	BLyS/TNFSF13B Protein, Recombinant	10056-HNCH
BLyS/TNFSF13B	Human	BLyS/TNFSF13B Protein, Recombinant, with Native	10056-HNAE

Beschreibung von BAFF / TNFSF13B Protein

Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), also known as B cell-activating factor, CD257 and BAFF, is single-pass type I I membrane protein. It belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression of BAFF is found in placenta, heart, lung, fetal liver, thymus, and pancreas. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors are expressed mainly on mature B lymphocytes, and TACI binds with lowest affinity. TACI binds a protein similar to BAFFcalled A Proliferation Inducing Ligand (APRIL) with high. BCMA displays an intermediate binding phenotype and performs functions with either BAFF or APRIL to varying degrees. BAFF acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells.

References

Shu HB. et al., 1999, J Leukoc Biol. 65 (5): 680-3.
Schneider P. et al., 1999, J Exp Med. 189 (11): 1747-56.
Wu Y. et al., 2000, J Biol Chem. 275 (45): 35478-85.
Oren DA. et al., 2002, Nat Struct Biol. 9: 288-92.
Daridon C. et al., 2008, Autoimmun Rev. 7 (4): 267-71.

Sino Biological Inc. liefert BAFF / TNFSF13B Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über BAFF / TNFSF13B Protein (Native) lesen Sie bitte: http://www.sinobiological.com/BAFF-TNFSF13B-Protein-g-8821.html