CREB3L1 / OASIS (aa 396-519) Protein (His Tag)

08.06.2013

Sino Biological Inc. liefert CREB3L1 / OASIS (aa 396-519) Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CREB3L1 / OASIS (aa 396-519) Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/CREB3L1-OASIS-Protein-Antibody-a-6260.html

Produkt-Information von CREB3L1 / OASIS Protein

Synonym	CREB3L1, OASIS
Protein Construction	A DNA sequence encoding the human CREB3L1 (Q96BA8-1) (Glu396- Ser519) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von CREB3L1 / OASIS Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CREB3L1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 396
Molecular Mass	The recombinant human CREB3L1 consists of 135 amino acids and predicts a molecular mass of 15.2 KDa. It migrates as an approximately 21-31 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von CREB3L1 / OASIS Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CREB3L1 / OASIS Protein

CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.

References

Denard B. et al., 2011, Cell Host Microbe. 10 (1): 65-74.
Debelenko LV. et al., 2011, 50 (12): 1054-62.
Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.