APLP1 / Amyloid-like protein 1 Protein (His Tag)

08.06.2013

Sino Biological Inc. liefert APLP1 / Amyloid-like protein 1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über APLP1 / Amyloid-like protein 1 Protein (His Tag) lesen Sie bitte:http://www.sinobiological.com/APLP1-Amyloid-like-protein-1-Protein-Antibody-a-6258.html

Produkt-Information von APLP1 / Amyloid-like protein 1 Protein

Synonym	APLP1
Protein Construction	A DNA sequence encoding the human APLP1 (P51693-1) (Met1-Glu580) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von APLP1 / Amyloid-like protein 1 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: APLP1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 39
Molecular Mass	The recombinant human APLP1 consists of 553 amino acids and predicts a molecular mass of 61.9 KDa. It migrates as an approximately 67-77 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von APLP1 / Amyloid-like protein 1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von APLP1 / Amyloid-like protein 1 Protein

APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose and insulin homeostasis. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.

References

Wasco W. et al., 1993, Genomics. 15 (1): 237-9.
Needham BE. et al., 2008, J Pathol. 215 (2): 155-63.
Bayer TA. et al., 2000, Mol Psychiatry. 4 (6): 524-8.
Lee S. et al., 2011, Biochemistry. 50 (24): 5453-64.