Contactin 1 / CNTN1 Antikörper

10.02.2012

Produkt-Information von Contactin 1 / CNTN1 Antkörper

Immunogen	Recombinant Human Contactin 1 / CNTN1 protein (Catalog#10383-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Contactin 1 / CNTN1 (rHuman Contactin 1 / CNTN1; Catalog#10383-H08H; NP_001834.2; Met 1-993). Contactin 1 / CNTN1 specific IgG was purified by Human Contactin 1 / CNTN1 affinity chromatography.

Contactin 1 / CNTN1 Antibody Usage Guide

Specificity	Human Contactin 1 / CNTN1
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CNTN1 in WB. Using a DAB detection system, the detection limit for Human CNTN1 is approximately 4 ng/lane under non-reducing conditions and 16 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CNTN1. The detection limit for Human CNTN1 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Contactin 1 / CNTN1 Antibody Related Products & Topics

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Contactin 1 / CNTN1 Antibody Background

Contactin-1 (CNTN1) is a member of the contactin sbufamily belonging to immunoglobulin superfamily. CNTN1 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein consisting of 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains, and is expressed in numerous neuronal tissues, as well as neuroblastoma and retinoblastoma cell lines. As a cell adhesion molecule, CNTN1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that CNTN1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1, and thus is involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that CNTN1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells.

References

Peles, E. et al., 1995, Cell. 82: 251-260.
Pierre, Kk. et al., 2001, Eur. J. Neurosci. 14: 645-656.
Su, J.L. et al., 2006, Cancer. Res.66: 2553-2561.

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