Leptin Receptor / CD295 / LEPR Antikörper (Antigen Affinität reinigt)

10.02.2012

Produkt-Information von Leptin Receptor / CD295 / LEPR Antikörper

Immunogen	Recombinant Human Leptin Receptor / CD295 / LEPR protein (Catalog#10322-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose

Leptin Receptor / CD295 / LEPR Antikörper Usage Guide

Specificity	Human Leptin Receptor / CD295 / LEPR
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human LEPR in WB. Using a DAB detection system, the detection limit for Human LEPR is approximately 2 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human LEPR. The detection limit for Human LEPR is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Leptin Receptor / CD295 / LEPR Antikörper

Leptin receptor (LEPR), also known as OB-R and B219, is a single-transmembrane-domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.

References

Tartaglia, L.A. et al., 1995, Cell. 83: 1263-1271.
Cioffi, J.A. et al., 1996, Nature Medicine 2: 585-589.
Couturier, C. et al., 2003, J. Biol. Chem. 278: 26604-26611.

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