SLAMF8 Antikörper (Antigen Affinität reinigt)

10.02.2012

Produkt-Information von SLAMF8 Antikörper

Immunogen	Recombinant Mouse SLAMF8 protein (Catalog#50623-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse SLAMF8 (rMouse SLAMF8;Catalog#50623-M08H; NP_083360.2; Met 1-Asp 231). SLAMF8 specific IgG was purified by Mouse SLAMF8 affinity chromatography.

SLAMF8 Antikörper Usage Guide

Specificity	Mouse SLAMF8
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse SLAMF8 in WB. Using a DAB detection system, the detection limit for Mouse SLAMF8 is approximately 2 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse SLAMF8. The detection limit for Mouse SLAMF8 is approximately 0.00245 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von SLAMF8 Antikörper

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains oneIg-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

References

Kingsbury G.A., et al., 2001, J. Immunol. 166: 5675-80.
Zhang Z., et al., 2004, Protein Sci. 13: 2819-24.
Veillette,A. et al.,2006, Nat Rev Immunol. 6 (1): 56-66.
Veillette,A. et al., 2006, Trends Immunol. 27 (5): 228-34.
Yan,Q. et al., 2007,Proc Natl Acad Sci. USA. 104 (25): 10583-8.

Sino Biological Inc. liefert SLAMF8 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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