COMMD9 Protein (His Tag)

13.05.2013

Sino Biological Inc. liefert COMMD9 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über COMMD9 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/COMMD9-Protein-Antibody-a-5918.html

Produkt-Information von COMMD9 Protein

Synonym	COMMD9
Protein Construction	A DNA sequence encoding the human COMMD9 (Q9P000-1) (Met1-Lys198) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von COMMD9 Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: COMMD9 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human COMMD9 consists of 213 amino acids and predicts a molecular mass of 23.7 KDa. It migrates as an approximately 25 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 10% Glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von COMMD9 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von COMMD9 Protein

COMMD9 is a COMM domain-containing or COMMD protein. COMMD family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. They represent a recently discovered set of evolutionarily conserved factors characterized by the presence of a defining carboxy-terminal motif. COMMD protein functions in the control of the transcription factor NFkappaB. NFkappaB plays a critical role in a number of homeostatic processes in multicellular organisms, including the regulation of immunity and cell survival. COMMD proteins inhibit NFkappaB mediated gene expression, and recent mechanistic studies have revealed that COMMD1 controls the ubiquitination of NFkappaB subunits, an event linked to transcriptional termination. COMMD1 binds to a multimeric ubiquitin ligase containing Elongins B/C, Cul2 and SOCS1 (ECS( SOCS1)). In this complex, COMMD1 facilitates the binding of NFkappaB subunits to the ligase, thereby promoting their ubiquitination and degradation. Additional insights gained from these studies indicate that COMMD proteins likely play a broader role in cellular homeostasis through their participation in the ubiquitination pathway.

References

Ota T. et al., 2004, Nat Genet. 36 (1): 40-5.
Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.
Burstein E. et al., 2005, J Biol Chem. 280 (23): 22222-32.