CDK2AP2 Protein (His Tag)

Produkt-Information von CDK2AP2 Protein

CDK2AP2 Protein QC Testing

Purity	> 78%(the upper band )+17%(the lower band) as determined by SDS-PAGE	SDS-PAGE: CDK2AP2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human CDK2AP2 consists of 136 amino acids and has a calculated molecular mass of 14.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human CDK2AP2 is approximately 18 and 12 kDa due to different glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, 15% glycerol, pH7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CDK2AP2 Protein

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Beschreibung von CDK2AP2 Protein

CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.

References

1. Stelzl U. et al., 2005, Cell. 122 (6): 957-68.
2. Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7.
3. Buajeeb W. et al., 2004, Biochem Biophys Res Commun. 315 (4): 998-1003.

Sino Biological Inc. liefert CDK2AP2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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