DDR2 / CD167b / NTRKR3 (aa 422-855) Protein (GST Tag)

24.09.2012

Produkt-Information von DDR2 / CD167b / NTRKR3 Protein

Synonym	DDR2, NTRKR3, TKT, TYRO10
Protein Construction	A DNA sequence encoding the human DDR2 (Q16832)(Arg422-Glu855) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Source	Human
Expression Host	Baculovirus-Insect cells

QC Testing von DDR2 / CD167b / NTRKR3 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: DDR2 / CD167b / NTRKR3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human DDR2 /GST chimera consists of 671 amino acids and has a calculated molecular mass of 77.1 kDa. The recombinant protein migrates as an approximately 77 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH 7.4, 10%glycerol. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von DDR2 / CD167b / NTRKR3 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von DDR2 / CD167b / NTRKR3 Protein

Related Areas:

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>DDR2/CD167b

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>DDR2/CD167b

Immunology>>Cluster of Differentiation>>DDR2/CD167b

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
DDR2	Human	DDR2/Fc Protein, Recombinant	10209-H02H
DDR2	Human	DDR2 / CD167b / NTRKR3 (aa 422-855) Protein, Recombinant, with GST Tag	10209-H20B1
DDR2	Human	DDR2 Protein, Recombinant	10209-HCCH
DDR2	Mouse	DDR2 Protein, Recombinant	50541-M08H
DDR2	Rat	DDR2 Protein, Recombinant	80341-R02H
DDR2	Rat	DDR2 Protein, Recombinant	80341-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse DDR2	WB, ELISA	DDR2 Antibody	50541-RP01
Mouse DDR2	WB, ELISA	DDR2 Antibody (Antigen Affinity Purified)	50541-RP02

Beschreibung von DDR2 / CD167b / NTRKR3 Protein

Discoidin domain receptor 2 (DDR2), also known as TYR010 and TKT, is a type I transmembrane glycoprotein and belongs to discoidin-like domain containing subfamily of receptor tyrosine kinases (RTKs). All family members share the discoidin (DS) homology domain, a long juxtamembrane domain, a transmembrane region, and a tyrosine kinase domain. DDR2 is mainly expressed in mesenchymal cells and is unique among RTKs in that its ligand is fibrillar collagen rather than a growth factor-like peptide. Ligand binding induces DDR2 autophosphorylation in the cytoplasmic domain and the adaptor proteins SHC have been identified as key signaling mediators in DDR2 signal transduction. Activation of DDR2 by collagen induces upregulation of MMP-1, -2, and -13 as well as DDR2 itself. It has been suggested that DDR2 plays an important role in mediating chondrocyte, hepatic stellate cells and fibroblast migration and proliferation by MMP2–dependent mechanism. Accordingly, aberrant expression of DDR2 is implicated in tumor growth and invasion.

References

Voqel W. et al., 1997, Mol Cell. 1: 13-23.
Alves F. et al., 1995, Oncogene. 10: 609-18.
Leitinqer B. et al., 2006. Matrix Biol. 25: 355-64.
Wall SJ. et al., 2005, J. Biol. Chem. 48: 40187-94.
Ferri N. et al., 2004, Am J Pathol. 164: 1575–85.
Ikeda K. et al., 2002, J Biol Chem. 277: 19206-12.

Sino Biological Inc. liefert DDR2 / CD167b / NTRKR3 (aa 422-855) Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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