CD8a Antikörper ( FITC )

Produkt-Information von CD8a Antikörper

Usage Guide von CD8a Antikörper

Specificity	Mouse CD8a
Flow Cytometry	BALB/c splenocytes were stained with FITC-conjugated anti-Mouse CD8a (50389-R208-F). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. Flow cytometric analysis of CD8a expression on spleen lymphocytes. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von CD8a Antikörper

Immunology>>Cluster of Differentiation>>CD8a

Hintergrund von CD8a Antikörper

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

References

1. Devine, L. et al., 2000, J Immunol. 164 (2): 833-8.
2. Arcaro, A. et al., 2000, J Immunol. 165 (4): 2068-76.
3. Saha, K. et al., 2001, Nat Med. 7 (1): 65-72.
4. Romero, P. et al., 2005, Eur J Immunol. 35 (11): 3092-4.

Sino Biological Inc. liefert CD8a Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD8a Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD8a-Antibody-g-8793.html