CD34 Antikörper ( FITC )

Produkt-Information von CD34 Antikörper

Usage Guide von CD34 Antikörper

Specificity	Mouse CD34
Flow Cytometry	Analysis of anti-mouse CD34 on M1 cells. Flow cytometric analysis of anti-mouse CD34 on M1 cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CD34 in WB. Using a DAB detection system, the detection limit for Mouse CD34 is approximately 0.25 ng/lane under reducing conditions. Use of this antibody under non-reducing conditions is not recommended.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD34

Hintergrund von CD34 Antikörper

CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.

References

1. Fackler, M.J. et al., 1990, J. Biol. Chem. 265: 11056-11061.
2. Simmons, D.L. et al., 1992, J. Immunol. 148: 267-271.
3. Latailade, J.J. et al., 2000, Blood. 95: 756-768.
4. Furness, S.G and McNagny, K. 2006, Immunol. Res. 34: 13-32.

Sino Biological Inc. liefert CD34 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD34 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD34-Antibody-g-8792.html