CD68 / Macrosialin / Gp110 (aa 1-319) Protein (His Tag)

Produkt-Information von CD68 / Macrosialin / Gp110 Protein

QC Testing von CD68 / Macrosialin / Gp110 Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: CD68 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 22
Molecular Mass	The secreted recombinant human CD68 consists of 308 amino acids and predicts a molecular mass of 32.9 KDa. The apparent molecular mass of the protein is approximately 68 Kda in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of 20mM Tris,500mM NaCl, pH7.4, 10% gly. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD68 / Macrosialin / Gp110 Protein

Verwandte Produkte & Themen von CD68 / Macrosialin / Gp110 Protein

Immunology>>Innate Immunity>>Monocyte/Macrophage>>Scavenger Receptor>>CD68

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CD68

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CD68

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD68

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD68

Cardiovascular>>Lipid Metabolism>>Scavenger Receptor>>CD68

Beschreibung von CD68 / Macrosialin / Gp110 Protein

Macrosialin, also known as CD68 and Gp110, is a single-pass type I  membrane protein which belongs to the LAMP family. CD68 is highly expressed by blood monocytes and tissue macrophages. It is also expressed in lymphocytes, fibroblasts and endothelial cells. CD68 is expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. CD68 plays a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It is a commonly used marker for macrophages. However, a number of studies have shown that CD68 antibodies react with other hematopoietic and non-hematopoietic cell types, suggesting that CD68 may not be a macrophage-specific antigen. CD68 binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

References

1. Strobl, H. et al., 1995, Br J Haematol. 90 (4): 774-82.
2. Ogawa,Y. et al., 1995, Pathol Int. 45 (9): 698-701.
3. Sadovnikova, E. et al., 2002,Leukemia. 16 (10): 2019-26.
4. Gottfried, E. et al., 2008, Scand J Immunol. 67 (5): 453-63.
5. Strojnik,T. et al., 2009, Anticancer Res. 29 (8): 3269-79.

Sino Biological Inc. liefert CD68 / Macrosialin / Gp110 (aa 1-319) Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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