CD64 / FCGR1 Antikörper

02.07.2012

Produkte & Themen von CD64 / FCGR1 Antikörper

Immunogen	Recombinant Mouse CD64 / FCGR1 protein (Catalog#50086-M08H)
Antibody Type	Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
Clone ID	008
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD64 / FCGR1 (rM CD64 / FCGR1; Catalog#50086-M08H; NP_034316.1; Met 1-Pro 297).

Usage Guide von CD64 / FCGR1 Antikörper

Specificity

Mouse CD64 / FCGR1

Has cross-reactivity in ELISA with

Mouse FCGR4

Mouse FCGR2B

Human CD16a

Human CD16b

Human CD32a

Human CD32b

Human CD64

Mouse FCGR3

Immunochemistry

IHC-P: 2-10 μg/mL

mFCGR1-mouse-brain immunohistochemistry mFCGR1-mouse-spleen immunohistochemistry

Immunochemical staining of mouse FCGR1 in mouse brain with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to microglia.

Immunochemical staining of mouse FCGR1 in mouse spleen with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to Kupffer cell.

Western blot

This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR1 in WB.

Direct ELISA

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse FCGR1.

Storage

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von CD64 / FCGR1 Antikörper

Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD64/FCGR1

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD64/FCGR1

Immunology>>Fc Receptor>>CD64/FCGR1

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD64/FCGR1	Human	CD64/FCGR1 Protein, Recombinant	10256-H08H
CD64/FCGR1	Human	CD64/FCGR1 Protein, Recombinant, with AVI Tag	10256-H27H
CD64/FCGR1	Human	CD64/FCGR1 Protein, Recombinant, with AVI Tag, Biotinylated	10256-H27H-B
CD64/FCGR1	Mouse	CD64/FCGR1 Protein, Recombinant	50086-M08H
CD64/FCGR1	Mouse	CD64/FCGR1 Protein, Recombinant, with AVI Tag	50086-M27H
CD64/FCGR1	Mouse	CD64/FCGR1 Protein, Recombinant, with AVI Tag, Biotinylated	50086-M27H-B
CD64/FCGR1	Rat	CD64/FCGR1 Protein, Recombinant	80016-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info.------CLICK!	Cat No
Human CD64/FCGR1	ELISA	Mouse Monoclonal Antibody	10256-MM06
Human CD64/FCGR1	WB	Mouse Monoclonal Antibody	10256-MM07
Human CD64/FCGR1	WB, ELISA	Rabbit Polyclonal Antibody	10256-RP01
Human CD64/FCGR1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10256-RP02
Mouse CD64/FCGR1	WB, ELISA	CD64/FCGR1 Antibody, Rabbit MAb	50086-R001
Mouse CD64/FCGR1	WB, ELISA, IHC-P	CD64 / FCGR1 Antibody	50086-R008
Mouse CD64/FCGR1	WB, ELISA	Rabbit Polyclonal Antibody	50086-RP01
Mouse CD64/FCGR1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50086-RP02
Rat CD64/FCGR1	WB, ELISA	CD64 / FCGR1A Antibody (Antigen Affinity Purified)	80016-RP02
Rat CD64/FCGR1	WB, ELISA	CD64 Antibody	80016-MM06

Hintergrund von CD64 / FCGR1 Antikörper

High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membraneglycoprotein and a member of the immunoglobulin superfamily. CD64 is a high affinity receptor for the Fc region of IgG gamma and functions in both innate and adaptive immune responses. Receptors that recognize the Fc portion of IgG function in the regulation of immune response and are divided into three classes designated CD64, CD32, and CD16. CD64 is structurally composed of asignal peptidethat allows its transport to the surface of a cell, threeextracellularimmunoglobulin domainsof the C2-type that it uses to bind antibody, a hydrophobictransmembrane domain, and a short cytoplasmic tail. CD64 isconstitutivelyfound on only macrophages and monocytes, but treatment of polymorphonuclear leukocyteswith cytokines likeIFNγandG-CSFcan induce CD64 expression on these cells. The inactivation of the mouse CD64 resulted in a wide range of defects in antibody Fc-dependent functions. Mouse CD64 is an early participant in Fc-dependent cell activation and in the development of immune responses.

References

Perussia, B. et al., 1983,J Exp Med. 158 (4): 1092-113.
Repp, R. et al., 1991, Blood. 78 (4): 885-9.
Ravetch, J. et al., 2001, Annu. Rev. Immunol. 19: 275-83.
Takai, T., 2002, Nature Rev. Immunol. 2: 580-92.
Barnes, N. et al., 2002, Immunity 16: 379-89.

Sino Biological Inc. liefert CD64 / FCGR1 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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