CD54 / ICAM1 Antikörper ( FITC )

Produkt-Information von CD54 / ICAM1 Antikörper

Usage Guide von CD54 / ICAM1 Antikörper

Specificity	Mouse CD54 / ICAM1
	No cross-reactivity in ELISA with Human ICAM1 Human CD31 Human ICAM3 Human ICAM2 Mouse VCAM1
Flow Cytometry	Naive BALB/c splenocytes were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) and stained with FITC-conjugated anti-Mouse ICAM1 (CD54) (50440-R009-F). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. Flow cytometric analysis of ICAM1 (CD54) expression on spleen lymphocytes. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse ICAM1 in WB under non-reducing conditions. Use of this antibody under reducing conditions is not recommended.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Adhesion>>ICAM-1/CD54

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells / T Cell Migration/Adhesion>>ICAM-1/CD54

Hintergrund von CD54 / ICAM1 Antikörper

ICAM1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration.ICAM1 is a ligand for LFA-1 (integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.

References

1. Rothlein, R. et al.,1986, Journal of Immunology. 137 (4): 1270-1274.
2. Yang, L. et al., 2005, Blood. 106 (2): 584-592.
3. Frijns, C.J. et al., 2002, Stroke. 33 (8): 2115-2122.
4. Bella, J.et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4140-4145.

Sino Biological Inc. liefert CD54 / ICAM1 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD54 / ICAM1 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD54-ICAM1-Antibody-g-8795.html