CD48 / SLAMF2 Antikörper ( FITC )

Produkt-Information von CD48 / SLAMF2 Antikörper

Usage Guide von CD48 / SLAMF2 Antikörper

Specificity	Mouse CD48 / SLAMF2
Flow Cytometry	BALB/c splenocytes were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) and stained with FITC-conjugated anti-Mouse CD48 (50415-R341-F). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes Flow cytometric analysis of CD48 expression on spleen lymphocytes. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CD48 in WB. Using a DAB detection system, the detection limit for Mouse CD48 is approximately 2 ng/lane under non-reducing conditions. Use of this antibody under reducing conditions is not recommended.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Hintergrund von CD48 / SLAMF2 Antikörper

CD48, also known as SLAMF2, BCM-1 and BLAST-1, is a 65 kDa GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. In rodents, CD48 is the ligand for CD2 whereas in humans, CD58 is the ligand for CD2. Human CD48 cDNA encodes a 243 aa precursor that includes a 26 aa signal sequence, a 194 aa mature protein that contains one Ig-like V-type domain and one Ig-like C2-type domain, and a 23 aa C-terminal propeptide. It has a high degree of sequence homology to CD58 (LFA-3), and human CD48 shares approximately 50% aa sequence identity with mouse and rat CD48. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.

References

1. Wong, Y.W. et al., 1990, J. Exp. Med. 171: 2115-2130.
2. Ianelli,C.J. et al., 1997,J Immunol. 159 (8): 3910-3920.
3. Ianelli, C.J. et al., 1998, J. Biol. Chem. 273: 23367-23375.
4. Loertscher, R. et al., 2002, Transpl. Immunol. 9: 93-96.
5. Assarsson, E. et al., 2005, J. Immunol. 175: 2045-2049.
6. Bhat, R. et al., 2006, J. Leukocyte Biol. 79: 417-424.

Sino Biological Inc. liefert CD48 / SLAMF2 Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD48 / SLAMF2 Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD48-SLAMF2-Antibody-g-8796.html