CD5 Antikörper

Produkt-Information von CD5 Antikörper

Usage Guide von CD5 Antikörper

Specificity	Mouse CD5
Flow Cytometry	Flow cytometric analysis of mouse CD5 expression on lymphocytes. Profile of mouse splenocytes(left panel) and thymocytes (right panel) analyzed on a FACSCalibur (BDIS, San Jose, CA). The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Hintergrund von CD5 Antikörper

T-cell surface glycoprotein CD5, also known as Lymphocyte antigen T1 and LEU1, is a single-pass type I membrane protein. CD5 contains 3SRCR domains and has been regarded as a possible B cell lineage marker differentiating subsets, CD5+ B cells (also termed B1 cells) and conventional B cells (or B2 cells). CD5 is expressed at various developmental and activation stages on human B cells. It is a well established negative regulator of TCR and BCR signalling. Increased expression of CD5 on either T cells or B cells protects against autoimmunity. CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. The physiological role of CD5 might be to control the generation of aberrant immune responses. In cancers, CD5 expression plays a role in the fate of tumour-specific T cells, rendering lymphocytes tolerant and unable to recognize and eliminate malignant cells. Development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

References

1. Heuring, AH. et al., 2001, The British journal of ophthalmology. 85 (4): 498-9.
2. Dalloul, A., 2009, Autoimmun Rev. 8 (4): 349-53.
3. Pospisil, R. et al., 2009, Mol Immunol. 46 (13): 2456-64.

Sino Biological Inc. liefert CD5 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD5 Antikörper lesen Sie bitte: http:www.sinobiological.com/CD5-Antibody-g-9354.html