PD-L1 / B7-H1 / CD274 Antikörper

Produkt-Information von PD-L1 / B7-H1 / CD274 Antikörper

Usage Guide von PD-L1 / B7-H1 / CD274 Antikörper

Specificity	Mouse PD-L1 / B7-H1 / CD274
Flow Cytometry	Flow cytometric analysis of CD274 expression on spleen lymphocytes. BALB/c splenocytes were stained with Mouse CD274 Monoclonal Ab (50010-R401), then a FITC-conjugated second step antibody. The histogram were derived from the gated events based on light scattering characteristics of lymphocytes. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Produkt-Information von PD-L1 / B7-H1 / CD274 Antikörper

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>PD-L1/B7-H1/CD274

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>PD-L1/B7-H1/CD274

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Other>>PD-L1/B7-H1/CD274

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>PD-L1/B7-H1/CD274

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>PD-L1/B7-H1/CD274

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Other>>PD-L1/B7-H1/CD274

Hintergrund von PD-L1 / B7-H1 / CD274 Antikörper

B7 homolog 1 (B7-H1), also called programmed death ligand 1 (PD-L1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between B7-H1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. As a costimulator, B7-H1 induces T-cell proliferation and preferentially the production of interleukin 10 and interferon gamma. Conversely, by binding to programmed death 1 receptors (PD-1) on activated T-cells and B-cells, B7-H1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, B7-H1 leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. B7-H1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

References

1. Dong, H. et al., 1999, Nat. Med. 5: 1365-1369.
2. Freeman, G.J. et al., 2000, J. Exp. Med. 192:1027-103.
3. Dong, H., et al., 2002, Nat. Med. 8: 793-800.
4. Tamura, H. et al., 2003, Int. J. Hematol. 78: 321-328.
5. Trabattoni, D. et al., 2003, Blood. 101: 2514-2520.

Sino Biological Inc. liefert PD-L1 / B7-H1 / CD274 Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PD-L1 / B7-H1 / CD274 Antikörper lesen Sie bitte: http:www.sinobiological.com/PD-L1-B7-H1-CD274-Antibody-g-9355.html