CD44 Antijkörper ( FITC )

Produkt-Information von CD44 Antikörper

Usage Guide von CD44 Antikörper

Specificity	Human CD44
Flow Cytometry	1. Profile of peripheral blood lymphocytes analyzed by flow cytometry. The fluorescence histograms were derived from events with the forward and side light-scatter characteristics of viable lymphocytes. 2. Profile of anti-CD44 reactivity on HeLa cells analyzed by flow cytometry. Flow cytometric analysis of anti-CD44 reactivity on HeLa cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von CD44 Antikörper

Immunology>>Cluster of Differentiation>>CD44

CD44 Antibody Background

CD44, short for Cluster of Differentiation 44, is an adhesion molecule of the hyaluronate receptor family. It is expressed in a large number of mammalian cell types. The adhesive function of CD44, like other molecules involved in inducible adhesion, is tightly regulated. Post-translational modifications, isoform expression, aggregation state, and protein associations all can affect the ligand binding properties of CD44, and these can vary depending on the cell type and the activation state of the cell. The principal ligand of CD44 is hyaluronan, and CD44 is involved in the metabolism of this compound. Furthermore, an increasing quantity of evidence suggests that CD44 has various functions related to inflammatory disease. CD44 deficiency induces severe liver injury. CD44-hyaluronate mediates in lymphocyte T and monocyte adhesion to the endothelium, stimulates proinflammatory cytokine release from macrophages and participates in dedifferentiation phenotype of smooth muscle cells from contractile state to synthetic one. CD44 acts in atherosclerotic plaque destabilization and neointimal proliferation after percutaneous vascular interventions. CD44 participates in many stages of atherosclerosis. CD44 also is a cell membrane protein often overexpressed on tumor cells and, being both a cell-cell and cell-extracellular matrix adhesion protein, is well positioned to contribute to this process.

References

1. Krettek A. et al.,2009, Cardiovasc Hematol Disord Drug Targets. 9 (4): 293-302.
2. Johnson P. et al., 2000, Biochem Pharmacol. 59 (5): 455-65.
3. Kimura K. et al., 2010, Curr Opin Drug Discov Devel. 13 (1): 96-103.
4. Protasiewicz J. et al., 2005, Pol Merkur Lekarski. 19 (112): 559-62.
5. Jothy S. 2003, Clin Exp Metastasis. 20 (3): 195-201.

Sino Biological Inc. liefert CD44 Antijkörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CD44 Antijkörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/CD44-Antibody-g-8815.html