CD38 Protein (Gflag Tag)

Produkt-Information von CD38 Protein

QC Testing von CD38 Protein

Purity	> 93 % as determined by SDS-PAGE	SDS-PAGE: CD38 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The secreted recombinant human CD38 comprises 285 amino acids with a predicted molecular mass of 33.2 kDa. As a result of glycosylation, rhCD38 migrates as an approximately 42-45 kDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD38 Protein

Verwandte Produtke & Themen von CD38 Protein

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD38

Cancer>>Cancer Stem Cell (CSC)>>CD38

Cancer>>Cancer Biomarkers>>CD38

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD38

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD38

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD38

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Regulatory T Cells>>CD38

Beschreibung von CD38 Protein

CD38, also known as ADP-ribosyl cyclase, is a transmembrane glycoprotein comprising two to four N-linked oligosaccharide chains containing sialic acid residues. It is expressed on the surface of immune cells including CD4+, CD8+, B and natural killer cells. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. CD38 functions in cell adhesion, signal transduction and calcium signaling. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic β cells. CD38 has a key role in neuropeptide release, thereby critically regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders. Defects of CD38 is associated with impaired immune responses, metabolic disturbances, and behavioral modifications, and has been connected to human immunodeficiency virus (HIV) infection, leukemias, myelomas, solid tumors, type I I diabetes mellitus and bone metabolism, as well as some genetically determined conditions. In addition, it was demonstrated that CD38 not only acts as a key modulator of the immune response, but also plays an equally important role as an intrinsic pulmonary component. CD38 as the main cellular NADase in mammalian tissues, and the characterization of its role on the control of cellular NAD levels indicate that CD38 may serve as a pharmacological target for multiple conditions.

References

1. Deaglio S. et al., 2001, Leuk Res. 25 (1): 1-12.
2. Jin D. et al., 2007, Nature. 446 (7131): 41-5.
3. Orciani M. et al., 2008, J Cell Biochem. 105 (3): 905-12.
4. Malavasi F. et al., 2008, Physiol Rev. 88 (3): 841-86.
5. Chini EN. et al., 2009, Curr Pharm Des. 15 (1): 57-63.

Sino Biological Inc. liefert CD38 Protein (Gflag Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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