CCNE1 / Cyclin-E1 Protein (GST Tag)

Produkt-Information von CCNE1 / Cyclin-E1 Protein

QC Testing von CCNE1 / Cyclin-E1 Protein

Purity	> 82 % as determined by SDS-PAGE	SDS-PAGE: CCNE1 / Cyclin-E1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human CCNE1/GST chimera consists of 647 amino acids and has a calculated molecular mass of 75 KDa. It migrates as an approximately 70 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of 20mM Tris,500mM NaCl,10% gly,1mM GSH,pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CCNE1 / Cyclin-E1 Protein

Verwandte Produkte & Themen von CCNE1 / Cyclin-E1 Protein

Cancer>>Cell Cycle>>Cyclin>>Cyclin E1/CCNE1

Beschreibung von CCNE1 / Cyclin-E1 Protein

G1 / S-specific cyclin-E1, also known as CCNE1 and CCNE, is a nucleus protein which belongs to the cyclin family and Cyclin E subfamily. CCNE1 is highly expressed in testis and placenta, and is expressed at low levels in bronchial epithelial cells. As a positive regulator of the cell cycle, CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. In numerous human tumors, CCNE1 expression is frequently dysregulated, while the mechanism leading to its dysregulation remains incompletely defined. CCNE1 interacts with a member of the CDK2 / CDK protein kinases to form a serine / threonine kinase holoenzyme complex, including CDK2, CABLES1 and CCNA1, and the cyclin subunit of CCNE1 imparts substrate specificity to the complex. It interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. CCNE1 is also a potential therapeutic target in ovarian cancer. CCNE1-targeted therapy may benefit ovarian cancer patients with CCNE1 amplification.

References

1. Desmedt C. et al., 2006, Int J Cancer. 119 (11): 2539-45.
2. Wang F. et al., 2009, BMB Rep. 42 (11): 725-30.
3. Nagel I. et al., 2009, Haematologica. 94 (7):1020-3.
4. Nakayama N. et al., 2010, Cancer. 116 (11): 2621-34.

Sino Biological Inc. liefert CCNE1 / Cyclin-E1 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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