CD32a / FCGR2A Protein (His Tag)

Produkt-Information von CD32a / FCGR2A Protein

CD32a / FCGR2A Protein QC Testing

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: CD32a / FCGR2A protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 34
Molecular Mass	The secreted recombinant human CD32a consists of 196 amino acids and predicts a molecular mass of 22 KDa. The apparent molecular mass of the protein is approximately 29-32 KDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD32a / FCGR2A Protein

Verwandte Produkte & Themen von CD32a / FCGR2A Protein

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CD32/FCGR2

Immunology>>Cluster of Differentiation>>Dendritic Cell CD Antigen>>Dendritic Cell Pathogen Recognition/Uptake>>CD32/FCGR2

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CD32/FCGR2

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD32/FCGR2

Immunology>>Fc Receptor>>CD32/FCGR2

Beschreibung von CD32a / FCGR2A Protein

Receptors that recognize the Fc portion of IgG (Fcγ Rs) functions in the regulation of immune response and are divided into three classes designated Fcγ RI (CD64), Fcγ RII (CD32), and Fcγ RIII (CD16). Fcγ RI binds IgG with high affinity and functions during early immune responses, whereas Fcγ RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Human CD32 class is encoded by three closely related genes, and designated Fcγ RII A, B, and C which share 94 - 99% amino acid identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. Fcγ RII A is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM (immunoreceptor tyrosine-based activation motif)- bearing adapter subunit, Fc Rγ, CD32a (Fcγ RII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

References

1. Stuart SG. et al., 1989, EMBO J. 8: 3657-66.
2. Ravetch J. et al., 2001, Annu Rev Immunol. 19: 275-83.
3. Takai T. 2002, Nature Rev Immunol. 2: 580-92.
4. Nagarajan S. et al., 2000, Blood. 3: 1069-77.

Sino Biological Inc. liefert CD32a / FCGR2A Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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