Autotaxin / ENPP2 / NPP2 Protein (His Tag)

Produkt-Information von Autotaxin / ENPP2 / NPP2 Protein

QC Testing von Autotaxin / ENPP2 / NPP2 Protein

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: Autotaxin / ENPP2 / NPP2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human ENPP2 consists of 834 amino acids and has a calculated molecular mass of 96 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhENPP2 is approximately 120-130 kDa due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von Autotaxin / ENPP2 / NPP2 Protein

Verwandte Produkte & Themen von Autotaxin / ENPP2 / NPP2 Protein

Enzyme>>Lipid Metabolism Enzymes>>Autotaxin/ENPP2

Lipid Metabolism>>Lipid Metabolism Enzymes>>Autotaxin/ENPP2

Beschreibung von Autotaxin / ENPP2 / NPP2 Protein

Autotaxin ( ATX ) also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 ( NPP2 or ENPP2 ). It belongs to the nucleotide pyrophosphatase/phosphodiesterase family. As a catalytic protein, Autotaxin possesses lysophospholipase D activity, and thus involved in cellular membrane lipid metabolism and remodeling. Autotaxin is discovered in human melanoma cells, has been gaining attention because it could be involved in cancer invasion and metastasis as an autocrine motility factor. Recent evidence has indicated that ATX is a key enzyme in the synthesis of lysophosphatidic acid (LPA), a lipid mediator with a wide range of biological actions including the stimulation of proliferation and contraction in hepatic stellate cells, a pivotal player in hepatic fibrosis. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. Thus, Autotaxin involves in several motility-related processes such as angiogenesis and neurite outgrowth. It was found acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Additionally, Autotaxin / ENPP2 was thought as a culprit protein for cancer, which potently stimulates cancer cell proliferation and tumor cell motility, augments the tumorigenicity and induces angiogenic responses.

References

1. Ikeda H. et al., 2009, Rinsho Byori. 57 (5): 445-9.
2. Boucher J. et al., 2005, Diabetologia. 48: 569-77.
3. Pradere J.P. et al., 2007, Biochim Biophys Acta. 1771: 93-102.
4. Tania M. et al., 2010, Biochem Biophys Res Commun. 401 (4): 493-7.

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