Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper ( FITC )

Produkt-Information von Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper

Usage Guide von Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper

Specificity	Human Cadherin-1 / CDH1 / CD324 / E-cadherin
Flow Cytometry	Flow cytometric analysis of anti-E-cad (CD324) reactivity. Profile of anti-E-cad (CD324) reactivity on MCF-7 cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Verwandte Produkte & Themen von Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>E-Cadherin/CDH1/CD324

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Stem Cell (CSC)>>E-Cadherin/CDH1/CD324

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Biomarkers>>E-Cadherin/CDH1/CD324

Immunology>>Adhesion Molecule>> Cadherin>>E-Cadherin/CDH1/CD324

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>E-Cadherin/CDH1/CD324

Immunology>>Cluster of Differentiation>>Other>>E-Cadherin/CDH1/CD324

Hintergrund von Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is the classical cadherin molecule and contains five cadherin domains of ~110 aa each in the extracellular domain. E-Cad is expressed in the non-neural epithelial tissues as disulfide-linked homodimer, and plays a key role in the organization and integrity of most epithelial tissues, cell differentiation and tissue development. CDH1 interacts directly, via the cytoplasmic domain, with CTNNB1 or JUP to form the PSEN1/cadherin/catenin adhesion complex which connects to the actin skeleton through the actin binding of alpha-catenin. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas (gastric, breast, ovary, endometrium and thyroid).

References

1. Berx G. et al., 1995, Genomics 26: 281-289.
2. Yoshiura K. et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92: 7416-7419.
3. Becker K.-F. et al., 1994, Cancer Res. 54: 3845-3852.
4. Marambaud P. et al., 2002, EMBO J. 21: 1948-1956.
5. Steinhusen U. et al., 2001, J. Biol. Chem. 276: 4972-4980.

Sino Biological Inc. liefert Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper ( FITC ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Cadherin-1 / CDH1 / CD324 / E-cadherin Antikörper ( FITC ) lesen Sie bitte: http://www.sinobiological.com/Cadherin-1-CDH1-CD324-E-cadherin-Antibody-g-8807.html