ICAM-1 / CD54 Antikörper ( PE )

16.05.2012

ICAM-1 / CD54 Antikörper

Immunogen	Recombinant Human ICAM-1 protein (Catalog#10346-H08H)
Reagents	PE-conjugated mouse monoclonal antibody
Clone ID	8B9H12
Ig Type	Mouse IgG1
Concentration	5 μl/Test, 0.2 mg/ml
Formulation	Aqueous solution containing 0.5% BSA and 0.1% sodium azide
Preparation	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICAM-1 / CD54 (rh ICAM-1 / CD54; Catalog#10346-H08H; NP_000192.2; Met 1-Glu 480) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Usage Guide von ICAM-1 / CD54 Antikörper

Specificity	Human ICAM-1 / CD54
	No cross-reactivity in ELISA with Human ICAM2 Human ICAM3 Human VCAM1 Human CD62E Human CEACAM1 Human cell lysate (293 cell line)
Flow Cytometry	Flow cytometric analysis of anti-ICAM1 (CD54) reactivity. Profile of anti-ICAM1 (CD54) reactivity on Daudi cells analyzed by flow cytometry. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Storage	This antibody is stable for 12 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Hintergrund von ICAM-1 / CD54 Antikörper

ICAM1 (Inter-Cellular Adhesion Molecule 1), also known as CD54, is a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. As an endothelial and leukocyte-associated transmembrane protein, ICAM1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration.ICAM1 is a ligand for LFA-1 (integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.

References

Rothlein, R. et al.,1986, Journal of Immunology. 137 (4): 1270-1274.
Yang, L. et al., 2005, Blood. 106 (2): 584-592.
Frijns, C.J. et al., 2002, Stroke. 33 (8): 2115-2122.
Bella, J.et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4140-4145.

Sino Biological Inc. liefert ICAM-1 / CD54 Antikörper ( PE ) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ICAM-1 / CD54 Antikörper ( PE ) lesen Sie bitte: http://www.sinobiological.com/ICAM-1-CD54-Antibody-g-8806.html

ICAM-1 / CD54 Antikörper ( PE )