CABP3 / CABP5 Protein (His Tag)

09.10.2012

Produkt-Information von CABP3 / CABP5 Protein

Synonym	CABP5, CABP3
Protein Construction	A DNA sequence encoding the mature form of human CABP5 (Q9NP86) (Met1-Arg173) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von CABP3 / CABP5 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: CABP3 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human CABP5 consists of 188 amino acids and predicts a molecular mass of 21.7 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, 0.1%Tween 20,50mM Arg, pH:7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CABP3 / CABP5 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CABP3 / CABP5 Protein

CABP3, also known as CABP5, is a member of the subfamily of calcium binding proteins. Calcium-binding proteins share similarity to calmodulin and participate in calcium cell signalling pathways by binding to Ca2+. Calcium-binding proteins play a key role in signal transduction and they also contribute to all aspects of the cell's functioning, from homeostasis to learning and memory. It has been shown that the mouse homolog of CABP3 express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. CABP3 inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. It is also involved in the transmission of light signals. Expression of this CABP3 is retina-specific. The specific function of this gene is unknown. CABP5 and CABP3 genes encode the protein products with distinct N-terminal halves but identical C-terminal halves.

References

McCauliffe DP. et al., 1990, J Clin Invest. 86 (1): 332-5.
Beutler E. et al., 1997, Mol Med. 3 (6): 397-402.
Michalak M. et al., 2002, Biochim Biophys Acta. 1600 (1-2): 32-7.

Sino Biological Inc. liefert CABP3 / CABP5 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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