BLOC1S2 / BLOS2 Protein (GST Tag)

17.10.2012

Produkt-Information von BLOC1S2 / BLOS2 Protein

Synonym	BLOC1S2, BLOS2, CEAP
Protein Construction	A DNA sequence encoding the human BLOC1S2 (Q6QNY1-2) (Met1-Arg99) was fused with the GST tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von BLOC1S2 / BLOS2 Protein

Purity	> 74 % as determined by SDS-PAGE	SDS-PAGE: BLOC1S2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human BLOC1S2 /GST chimera consists of 333 amino acids and has a predicted molecular mass of 38.7 kDa. It migrates as an approximately 39 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von BLOC1S2 / BLOS2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von BLOC1S2 / BLOS2 Protein

BLOC1S2, also known as BLOS2, is a member of the BLOC1S2 family. It interacts with IFT57 and is part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. BLOC1S2 gene has been proposed to participate in processes (melanosome organization, microtubule nucleation, platelet dense granule organization, positive regulation of cell proliferation, positive regulation of transcription, regulation of apoptosis, positive regulation of transcription from RNA polymerase II promoter). BLOC1S2 interacts directly with BLOC1S1, BLOC1S3, MUTED, CNO/cappuccino and SNAPIN. It may play a role in cell proliferation. It also plays a role in intracellular vesicle trafficking.

References

Sowa ME. et al., 2009, Cell. 138 (2): 389-403.
Gdynia G. et al., 2008, Apoptosis. 13 (3): 437-47.
Starcevic M. et al., 2004, J Biol Chem. 279 (27): 28393-401.

Sino Biological Inc. liefert BLOC1S2 / BLOS2 Protein (GST Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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