ARL2BP Protein (His Tag)

09.05.2013

Sino Biological Inc. liefert ARL2BP Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über ARL2BP Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/ARL2BP-BART1-Protein-Antibody-a-5911.html

Produkt-Information von ARL2BP Protein

Synonym	ARL2BP, BART, BART1
Protein Construction	A DNA sequence encoding the mature form of human ARL2BP (Q9Y2Y0-1) (Met1-His163) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von ARL2BP Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: ARL2BP protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human ARL2BP consists of 178 amino acids and predicts a molecular mass of 20.7 KDa. It migrates as an approximately 21 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von ARL2BP Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von ARL2BP Protein

ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of ARL2BP or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. ARL2BP is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. ARL2BP, together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. ARL2BP may play a role as an effector of ARL2.

References

Qiu J. et al., 2011, PLoS Pathog. 7 (8): e1002193.
Taniuchi K. et al., 2012, PLoS One. 7 (4): e35674.
Taniuchi K. et al., 2012, Neoplasia. 14 (5): 440-50.