Adiponectin / Acrp30 / ADIPOQ Protein

Produkt-Information von ADIPOQ/ ACDC Protein

QC Testing von ADIPOQ/ ACDC Protein

Purity	>97 % as determined by SDS-PAGE	SDS-PAGE: ADIPOQ/ ACDC protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 19
Molecular Mass	The recombinant human ADIPOQ /Fc is a disulfide-linked homodimer. The reduced monomer comprises 467 amino acids and has a predicted molecular mass of 51.6 kDa. The apparent molecular mass of the protein is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ADIPOQ/ ACDC Protein

Verwandte Produkte & Themen von ADIPOQ/ ACDC Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>Adiponectin/Acrp30/ADIPOQ

Beschreibung von ADIPOQ/ ACDC Protein

Adiponectin (ADIPOQ), also known as Adipocyte, C1q and collagen domain-containing protein, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, gelatin-binding protein, ADIPOQ and ACDC, is a secreted protein which contains oneC1q domain and onecollagen-like domain. Adiponectin/Acrp30/ADIPOQ is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin/Acrp30/ADIPOQ stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin/Acrp30/ADIPOQ antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Adiponectin/Acrp30/ADIPOQ inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

References

1. Maeda K. et al., 1996, Biochem Biophys Res Commun. 221: 286-9.
2. Saito K. et al., 1999, Gene. 229: 67-73.
3. Yamauchi T. et al., 2001, Nat Med. 7: 941-6.
4. Zhang Z. et al., 2004, Protein Sci. 13: 2819-24.
5. Takahashi M. et al., 2000, Int J Obes Relat Metab Disord. 24: 861-8.

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