TSPAN8 / Tetraspanin 8 / TM4SF3 Protein (His Tag)

22.05.2013

Sino Biological Inc. liefert TSPAN8 / Tetraspanin 8 / TM4SF3 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über TSPAN8 / Tetraspanin 8 / TM4SF3 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/TSPAN8-Tetraspanin 8-TM4SF3-Protein-g-11777.html

Produkt-Information von TSPAN8 / Tetraspanin 8 / TM4SF3 Protein

Synonym :	TSPAN8, TM4SF3
Protein Construction:	A DNA sequence encoding the human TSPAN8 (P19075) (Lys110-Asn205) was expressed with an N-terminal polyhistidine tag.
Source:	Human
Expression Host:	Human Cells

QC Testing von TSPAN8 / Tetraspanin 8 / TM4SF3 Protein

Purity:	(87.8+10.7) % as determined by SDS-PAGE	SDS-PAGE: TSPAN8 protein
Endotoxin:	< 1.0 EU per μg of the protein as determined by the LAL method
Stability:	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal:	His
Molecular Mass:	The recombinant human TSPAN8 comprises 116 amino acids and has a predicted molecular mass of 13.4 kDa. The apparent molecular mass of the protein is approximately 17 and 13 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation:	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von TSPAN8 / Tetraspanin 8 / TM4SF3 Protein

Storage:	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreiung von TSPAN8 / Tetraspanin 8 / TM4SF3 Protein

TSPAN8, also known as tetraspanin 8 and TM4SF3, is a member of the transmembrane 4 superfamily. Most members of this family are cell-surface proteins that are characterized by the presence of four hydrophobic domains. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN8 gene is expressed in different carcinomas. TSPAN8 is a cell surface glycoprotein that is known to complex with integrins. TSPAN8 is also known to efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins. TSPAN8 contributed to a selective recruitment of proteins and mRNA into exosomes, including CD106 and CD49d.

References

Szala S. et al., 1990, Proc Natl Acad Sci. 87 (17): 6833-7.
Berditchevski F. et al., 2002, J Cell Sci. 114 (23): 4143-51.
Maruyama K. et al., 1994, Gene. 138 (1-2): 171-4.
Nazarenko I. et al., 2010, Cancer Res. 70 (4): 1668-78.