Tryptophan Hydroxylase 1 / TPH1 Antikörper (Antigen Affinität reinigt)

07.02.2012

Produkt-Information von Tryptophan Hydroxylase 1 / TPH1 Antikörper

Immunogen	Recombinant Human Tryptophan Hydroxylase 1 / TPH1 protein (Catalog#11931-H07E)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human Tryptophan Hydroxylase 1 / TPH1 (rh Tryptophan Hydroxylase 1 / TPH1; Catalog#11931-H07E; P17752-1; Ile 2-Ile 444). Tryptophan Hydroxylase 1 / TPH1 specific IgG was purified by Human Tryptophan Hydroxylase 1 / TPH1 affinity chromatography.

Tryptophan Hydroxylase 1 / TPH1 Antikörper Usage Guide

Specificity	Human Tryptophan Hydroxylase 1 / TPH1
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TPH1 in WB. Using a DAB detection system, the detection limit for Human TPH1 is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TPH1. The detection limit for Human TPH1 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von Tryptophan Hydroxylase 1 / TPH1 Antikörper

Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is anenzyme which belongs to thebiopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains oneACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.

References

Antonia S. New, et al.,1998, American Journal of Medical Genetics Part B. 81 (1): 13-17.
Y. C Wang, et al.,2001, Neuropsychobiology. 43 (1): 1-4.
Diego J. et al., 2003, Science. 299 (5603): 76.
Allen NC, et al.,2008, Nat Genet.40 (7): 827-34.
Galfalvy,H. et al., 2009, J Affect Disord. 115 (3): 331-8.

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