IL-1F6 Antikörper (Antigen Affinität reinigt)

07.02.2012

Produkte-Information von IL-1F6 Antikörper

Immunogen	Recombinant Mouse IL-1F6 protein (Catalog#50095-HNAE)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse IL-1F6 (rM IL-1F6; Catalog#50095-HNAE; Q9JLA2-1; Met 1-His 160). IL-1F6 specific IgG was purified by Mouse IL-1F6 affinity chromatography.

IL-1F6 AntikörperUsage Guide

Specificity	Mouse IL-1F6
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL1F6 in WB. Using a DAB detection system, the detection limit for Mouse IL1F6 is approximately 1 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse IL1F6. The detection limit for Mouse IL1F6 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von IL-1F6 Antikörper

Interleukin-1 family member 6, also known as IL-1F6, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, IL1F6 and FIL1E, is a secreted protein which belongs to the IL-1 family. IL-1F6 is a new IL-1 family member. IL1F6 / FIL1E is expressed in immune system, fetal brain and adipose tissue and that IL-1F6 and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-1F6 inhibits PPARγ expression which may lead to reduced adipocyte differentiation suggesting metabolic effects of this cytokine.. IL1F6 / FIL1E, along with IL-36β / IL-1F8 and IL-36γ / IL-1F9, has been shown to act as an agonist by activating the pathway involving NF-κB and MAPK in an IL-1 Rrp2 dependent manner. IL1F6 / FIL1E may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

References

Smith DE. et al., 2000, J Biol Chem. 275:1169-1175.
Dunn E. et al. 2001, Trends Immunol. 22-53.
Nicklin MJ. et al., 2002, Genomics. 79 (5): 718-25.
Blumberg H. et al., 2007, J Exp Med. 204 (11): 2603-14.
Dinarello C. et al., 2010, Nat Immunol. 11: 973.

Sino Biological Inc. liefert IL-1F6 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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