TROP2 / TACSTD2 Antikörper ( FITC )

Produkt-Information von TROP2 / TACSTD2 Antikörper

TROP2 / TACSTD2 Antikörper Usage Guide

Specificity	Human TROP2 / TACSTD2
	No cross-reactivity in ELISA with Human E-cad Human CD146 Human CD171 Human BCAM Human VCAM1 Human ICAM1 Human cell lysate (293 cell line)
Flow Cytometry	MCF-7 cells were detached using 1X trypsin, washed, then stained with FITC Mouse anti-human TROP2. Flow cytometric analysis of anti-human TROP2 on MCF-7 cells. Flow cytometry was performed on a BD FACSCalibur flow cytometry system Please refer to www.sinobiological.com/Flow-Cytometry-FACS-Protocols-a-750.html for technical protocols.
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human TROP2 in WB.
Storage	This antibody is stable for 24 months from date of receipt when stored at 2℃- 8℃. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

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Hintergrund von TROP2 / TACSTD2 Antikörper

TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

References

Sino Biological Inc. liefert TROP2 / TACSTD2 Antikörper mit höherer Qualität und günstigen Kosten im Vergleich mit anderen globalen Lieferanten.

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