TREML1 Antikörper (Antigen Affinität reinigt)

16.02.2012

Produkt-Information von TREML1 Antibody Product Information

Immunogen	Recombinant Human TREML1 protein (Catalog#11934-H08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Human TREML1 (rh TREML1;Catalog#11934-H08H; Q86YW5-1; Met 1-Pro 162). TREML1 specific IgG was purified by Human TREML1 affinity chromatography.

TREML1 Antikörper Usage Guide

Specificity	Human TREML1
Western blot	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TREML1 in WB. Using a DAB detection system, the detection limit for Human TREML1 is approximately 2 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human TREML1. The detection limit for Human TREML1 is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

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Hintergrund von TREML1 Antikörper

Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) domain, its longer cytoplasmic tail is composed of both a proline-rich region and an immune receptor tyrosine-based inhibitory motif, the latter known to be used for interactions with protein tyrosine phosphatases. The triggering receptors expressed on myeloid cells (TREMs) have drawn considerable attention due to their ability to activate multiple cell types within the innate immune system, including neutrophils, monocyte / macrophages, and dendritic cells, via their association with DAP12. TREML1 / TLT-1 is prepackaged, along with CD62P, into both MK and platelet alpha-granules. Differences in thrombin-induced redistribution of CD62P and TREML1 indicate that TREML1 is not simply cargo of alpha-granules but may instead regulate granule construction or dispersal. TREML1 / TLT-1 does not function to inhibit members of the TREM family but instead may play a role in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.

References

Washington AV. et al., 2002, Blood. 100: 3822-4.
Allcock RJN. et al., 2003, Eur J Immunol. 33: 567-77.
Washington AV. et al., 2004, Blood. 104: 1042-7.
Barrow AD. et al., 2004, J Immunol. 172: 5838-42.
Gattis JL. et al., 2006, J Biol Chem. 281: 13396-403.

Sino Biological Inc. liefert TREML1 Antikörper (Antigen Affinität reinigt) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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